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\u4e8c\u6c27\u5316\u78b3\uff1b\u6e29\u5ea6\uff1a37\u2103\uff08\u57f9\u517b\u7bb1\u6e7f\u5ea6\u7ef4\u6301\u5728 70%-80%\uff0c\u5b9a\u671f\u66f4\u6362\u6c34\u76d8\uff0c\u9632\u6b62\u57f9\u517b\u57fa\u84b8\u53d1\u5bfc\u81f4\u6e17\u900f\u538b\u5347\u9ad8\uff0c\u4e0e 769-P \u57f9\u517b\u6761\u4ef6\u5b8c\u5168\u4e00\u81f4\uff0c\u786e\u4fdd\u4e24\u682a\u7ec6\u80de\u5b9e\u9a8c\u73af\u5883\u7684\u7edf\u4e00\u6027\uff09<\/li>\n<\/ul>\n<ul>\n<li class=\"temp-li bullet1\" data-line=\"true\" data-list=\"bullet1\">\u500d\u589e\u65f6\u95f4\uff1a~24-45 hours\uff08\u589e\u6b96\u901f\u5ea6\u8303\u56f4\u8f83\u5bbd\uff0c\u5bf9\u6570\u751f\u957f\u671f\u4e3a\u63a5\u79cd\u540e 1-3 \u5929\uff0c\u9700\u6839\u636e\u5b9e\u9645\u7ec6\u80de\u5bc6\u5ea6\u8c03\u6574\u4f20\u4ee3\u65f6\u95f4\uff1b\u76f8\u8f83\u4e8e 769-P \u7684 35 \u5c0f\u65f6\u56fa\u5b9a\u500d\u589e\u65f6\u95f4\uff0c\u9700\u5728\u5b9e\u9a8c\u8bbe\u8ba1\u4e2d\u589e\u52a0\u5bc6\u5ea6\u76d1\u6d4b\u9891\u7387\uff0c\u5efa\u8bae\u6bcf\u5929\u89c2\u5bdf\u7ec6\u80de\u751f\u957f\u72b6\u6001\uff0c\u5728\u5bc6\u5ea6\u8fbe 70%-80% \u65f6\u8fdb\u884c\u5b9e\u9a8c\u5904\u7406\uff09<\/li>\n<\/ul>\n<ul>\n<li class=\"temp-li bullet1\" data-line=\"true\" data-list=\"bullet1\">\u81f4\u7624\u6027\uff1aYes, in immunosuppressed hamsters.\uff08\u660e\u786e\u7684\u4f53\u5185\u81f4\u7624\u6027\uff0c\u53ef\u5728\u514d\u75ab\u6291\u5236\u4ed3\u9f20\u4e2d\u5f62\u6210\u80bf\u7624\uff0c\u9002\u7528\u4e8e\u4f53\u5185\u80bf\u7624\u6a21\u578b\u6784\u5efa\u3001\u836f\u7269\u4f53\u5185 efficacy \u8bc4\u4f30\uff1b\u867d\u672a\u63d0\u53ca\u88f8\u9f20\u6210\u7624\u6027\uff0c\u4f46\u53ef\u53c2\u8003 769-P \u7684\u88f8\u9f20\u6210\u7624\u7279\u6027\u5f00\u5c55\u9884\u5b9e\u9a8c\uff0c\u9a8c\u8bc1\u5176\u5728\u88f8\u9f20\u4e2d\u7684\u9002\u7528\u6027\uff0c\u62d3\u5c55\u4f53\u5185\u5b9e\u9a8c\u573a\u666f\uff09<\/li>\n<\/ul>\n<ul>\n<li class=\"temp-li bullet1\" data-line=\"true\" data-list=\"bullet1\">\u51bb\u5b58\u6761\u4ef6\uff1a\u65e0\u8840\u6e05\u51bb\u5b58\u6db2\uff0c\u6db2\u6c2e\u50a8\u5b58\uff08\u51bb\u5b58\u64cd\u4f5c\u6d41\u7a0b\u4e0e 769-P \u4e00\u81f4\uff1a\u2460\u5bf9\u6570\u751f\u957f\u671f\u7ec6\u80de\u6d88\u5316\u79bb\u5fc3\uff0c\u9884\u51b7\u51bb\u5b58\u6db2\u91cd\u60ac\uff08\u6d53\u5ea6 1\u00d710\u2076-5\u00d710\u2076cells\/mL\uff09\uff1b\u24614\u2103\u5e73\u8861 30 \u5206\u949f\u2192-20\u2103\u653e\u7f6e 2 \u5c0f\u65f6\uff08\u5efa\u8bae\u7528\u7a0b\u5e8f\u964d\u6e29\u76d2\uff09\u2192-80\u2103\u8fc7\u591c\u2192\u6db2\u6c2e\u4fdd\u5b58\uff1b\u590d\u82cf\u65f6 37\u2103\u6c34\u6d74 1 \u5206\u949f\u878d\u5316\uff0c\u79bb\u5fc3\u53bb\u51bb\u5b58\u6db2\uff0c\u65b0\u9c9c\u57f9\u517b\u57fa\u91cd\u60ac\uff09<\/li>\n<\/ul>\n<ul>\n<li class=\"temp-li bullet1\" data-line=\"true\" data-list=\"bullet1\">\u7ec6\u80de\u8d27\u671f\uff1a\u73b0\u8d27\uff0c1 \u5468\u5de6\u53f3\uff08\u5e93\u5b58\u5145\u8db3\uff0c\u6240\u6709\u73b0\u8d27\u7ec6\u80de\u5747\u7ecf\u8fc7\u6d3b\u6027\u68c0\u6d4b\u53ca PTH \u6837\u591a\u80bd\u5206\u6ccc\u9a8c\u8bc1\uff0c\u4e0b\u5355\u540e 48 \u5c0f\u65f6\u5185\u53ef\u5b89\u6392\u53d1\u8d27\uff0c\u7279\u6b8a\u9700\u6c42\u5982\u52a0\u6025\u63d0\u4f9b\u591a\u80bd\u5206\u6ccc\u68c0\u6d4b\u62a5\u544a\uff0c\u53ef\u63d0\u524d\u6c9f\u901a\uff09<\/li>\n<\/ul>\n<ul>\n<li class=\"temp-li bullet1\" data-line=\"true\" data-list=\"bullet1\">\u8fd0\u8f93\u65b9\u5f0f\uff1a\u590d\u82cf\u53d1\u8d27\uff08T25 \u74f6\u514d\u8fd0\u8f93\u8d39\u7528\uff0c\u91c7\u7528\u6052\u6e29\u6ce1\u6cab\u7bb1\u5185\u7f6e 2-8\u2103\u51b0\u888b\u53ca\u6e29\u5ea6\u76d1\u6d4b\u5361\uff0c\u5230\u8fbe\u540e\u7acb\u5373\u653e\u5165\u57f9\u517b\u7bb1\uff0c\u4e0e 769-P \u8fd0\u8f93\u8981\u6c42\u4e00\u81f4\uff09\/ \u51bb\u5b58\u53d1\u8d27\uff08\u9700\u52a0\u5e72\u51b0\u8fd0\u8f93\u8d39\u7528\uff0c\u786e\u4fdd\u5e72\u51b0\u5269\u4f59\u91cf\u226550%\uff09 \u987a\u4e30\u5feb\u9012\uff08\u4f18\u5148\u6b21\u65e5\u8fbe\u670d\u52a1\uff0c\u7f29\u77ed\u8fd0\u8f93\u65f6\u95f4\uff09<\/li>\n<\/ul>\n<ul>\n<li class=\"temp-li bullet1\" data-line=\"true\" data-list=\"bullet1\">\u4f9b\u5e94\u9650\u5236\uff1a\u4ec5\u9650\u4e8e\u79d1\u5b66\u7814\u7a76\uff0c\u7edd\u4e0d\u53ef\u4f5c\u4e3a\u52a8\u7269\u6216\u4eba\u7c7b\u75be\u75c5\u7684\u6cbb\u7597\u4ea7\u54c1\u4f7f\u7528\uff08\u4e25\u7981\u7528\u4e8e\u4e34\u5e8a\u6cbb\u7597\u3001\u7ec6\u80de\u6cbb\u7597\u7b49\u975e\u79d1\u7814\u7528\u9014\uff0c\u9700\u7b26\u5408\u300a\u4f53\u5916\u57f9\u517b\u52a8\u7269\u7ec6\u80de\u7cfb\u7ba1\u7406\u89c4\u8303\u300b\uff0c\u4e0e 769-P \u4f9b\u5e94\u9650\u5236\u6761\u6b3e\u4e00\u81f4\uff09<\/li>\n<\/ul>\n<ul>\n<li class=\"temp-li bullet1\" data-line=\"true\" data-list=\"bullet1\">\u7279\u522b\u8bf4\u660e\uff1a\u4ee5\u4e0b\u7ec6\u80de\u57f9\u517b\u51bb\u5b58\u5904\u7406\u4ec5\u4f9b\u53c2\u8003\uff0c\u5177\u4f53\u64cd\u4f5c\u6b65\u9aa4\u4ee5\u968f\u8d27\u4ea7\u54c1\u8bf4\u660e\u4e66\u4e3a\u4e3b\uff1b\u8be5\u7ec6\u80de\u5b9e\u9a8c\u64cd\u4f5c\u9700\u91cd\u70b9\u5173\u6ce8\uff1a\u2460\u4f20\u4ee3\u4e0e\u5bc6\u5ea6\u63a7\u5236\uff1a\u56e0\u500d\u589e\u65f6\u95f4\u8303\u56f4\u5bbd\uff0c\u9700\u6bcf\u5929\u955c\u68c0\u7ec6\u80de\u5bc6\u5ea6\uff0c\u907f\u514d\u8fc7\u5ea6\u5bc6\u96c6\u5bfc\u81f4\u7ec6\u80de\u8131\u843d\uff1b\u6d88\u5316\u65f6\u7528 0.25% \u80f0\u9176 &#8211; EDTA \u5b75\u80b2 2-3 \u5206\u949f\uff0c\u955c\u4e0b\u89c1\u7ec6\u80de\u95f4\u9699\u589e\u5927\u5373\u53ef\u7ec8\u6b62\uff0c\u8f7b\u67d4\u5439\u6253\u907f\u514d\u635f\u4f24\uff1b\u2461PTH \u6837\u591a\u80bd\u68c0\u6d4b\uff1a\u82e5\u5f00\u5c55\u591a\u80bd\u76f8\u5173\u5b9e\u9a8c\uff0c\u5efa\u8bae\u6536\u96c6\u57f9\u517b 48 \u5c0f\u65f6\u7684\u4e0a\u6e05\u6db2\uff0c\u901a\u8fc7 ELISA \u6cd5\u68c0\u6d4b\u591a\u80bd\u542b\u91cf\uff0c\u540c\u65f6\u8bbe\u7f6e\u65e0\u7ec6\u80de\u57f9\u517b\u57fa\u5bf9\u7167\uff0c\u6392\u9664\u80cc\u666f\u5e72\u6270\uff1b\u2462\u4e0e 769-P \u7684\u5bf9\u7167\u5b9e\u9a8c\u8bbe\u8ba1\uff1a\u4e24\u8005\u540c\u5c5e\u80be\u900f\u660e\u7ec6\u80de\u817a\u764c\uff0c\u53ef\u8bbe\u7f6e\u5e73\u884c\u5b9e\u9a8c\u7ec4\u9a8c\u8bc1\u836f\u7269\u654f\u611f\u6027\u3001\u57fa\u56e0\u529f\u80fd\u7b49\u7ed3\u679c\u7684\u4e9a\u578b\u901a\u7528\u6027\uff0c\u5982\u5bf9\u6bd4\u4e24\u682a\u7ec6\u80de\u5bf9\u9776\u5411\u836f\u7269\u7684 IC50 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